Larvicidal activity is certainly judged with a measurement called LC50. The LC50 value is the focus that kills 50 % of mosquito larvae in a day, Chang explains. Lower LC50 results in higher activity, because it takes a lower focus to kill larvae in the same amount of time. All four compounds had LC50 values of less than 50 parts per million , with cinnamaldehyde showing the strongest activity at an LC50 of 29 ppm. Cinnamaldehyde may be the main element in cinnamon bark oil and can be used in flavoring compounds to impart a cinnamon flavor... Bristol-Myers Squibb and Roche Enter into a Clinical Collaboration Agreement Bristol-Myers Squibb Company has entered directly into a clinical collaboration agreement with Roche to judge the utility of Bristol-Myers Squibb’s CTLA-4 inhibitor, YERVOY , in conjunction with Roche’s investigational oral BRAF inhibitor, vemurafenib, in treating patients with a particular type of metastatic melanoma. Under the agreement, both companies will carry out a Phase I/II research to evaluate the security and efficacy of the mixture. If appropriate, the firms may conduct further advancement of the combination. This agreement represents a significant cross-company collaboration exploring the potential role of the regimen in the treating metastatic melanoma. ‘Metastatic melanoma is one of the most aggressive types of malignancy,’ stated Brian Daniels, senior vice president, Medical and Development Affairs, Bristol-Myers Squibb.


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